There have been a few issues reported on the RpR forum about compatibility issues between Hidden and Dangerous 2 and Windows 10, so I am just going to give a few solutions here to those having the same problems.

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Take the sniper + 1 or 2 buddies (leave one man with pilot) & head towards the truck on the road, look due North for an enemy lying prone in the trees, snipe him and watch for another behind and to the left of the truck, run into the dip below and let the driving truck reach the truck you blocked the road with, when it hits lob a grenade (or two) at them and both should explode killing all on board. Hidden & Dangerous 2 is the stand-alone sequel to the 1999 original Hidden & Dangerous, which was extremely popular in Europe as well as in the United States. This episode puts players in the role of Lieutenant Gary Bristol, who became a member of the British Special Operation Section at the beginning of World War II.

The first is a CTD when launching the game.

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Some users reported the game would crash imeadiatly after launching, with no other error message. The current fix for this is to:
Open the HD2 setup (located in the H&D2 main directory) as an administrator
Disable fullscreen antiailiasing (2x and 4x will cause a fatal error)

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Save changes, and run H&D2 as administrator

Hidden And Dangerous 2

Next, people have been experiencing the game running in a window, even while in fullscreen mode. This causes parts of the screen to be cut off or otherwise not-visible.

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The solution for this is as-yet unknown. Disabling the game running fullscreen may help, though this has not been proven. Others are saying that the problem has fixed itself after some time.
I will edit/reply to this post as more information surfaces.